Is there a higher prevalence of amyloidosis in African Americans?

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Is there a higher prevalence of amyloidosis in African-Americans?

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So it's a great question. So regarding the increased prevalence of the T11 14 or translocation of chromosomes, 11 and 14, there's a higher prevalence of that in African-Americans with multiple myeloma.

00:00:25:02 - 00:00:48:09
 
and similarly we see an increased rate of that translocation in amyloidosis. And so it's an interesting, interesting thought as to whether those two things are connected. The long story short is that we haven't made that direct connection in the sense that, again, we know that t 1114 more common in amyloidosis, more common in African-Americans, and we know that amyloidosis is more common in African-Americans.

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But whether it's because they have a higher rate of this t 1114 translocation, that's unclear at this point. It makes sense, but we just haven't proven that yet.