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A Phase 2 Randomized, Open Label Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma


Description

The purpose of this study is to assess the efficacy and safety of golcadomide in combination with rituximab in participants with newly diagnosed advanced stage Follicular Lymphoma (FL).

Trial Eligibility

Inclusion Criteria * Participant has histologically confirmed Grade 1, 2 or 3a follicular lymphoma (FL) or classic FL. Formalin-fixed paraffin embedded (FFPE) archival tissue from 1 year prior to screening is allowed. If more than 1 year has passed, then a fresh biopsy must be obtained to confirm the diagnosis. * Have no prior systemic treatment for follicular lymphoma. Prior radiation therapy or surgery for previously diagnosed stage I disease is acceptable. * Stage II to IV disease. * Deemed to need treatment by treating investigator. Reasons for treatment can include, but are not limited to, the following:. i) Bulky disease defined as:. A. A nodal or extra nodal (except spleen) mass \> 7cm in its greater diameter or, involvement of at least 3 nodal or extra nodal sites (each with a diameter greater than \>3 cm). ii) Presence of at least one of the following B symptoms:. A. Fever (\>38°C) of unclear etiology. B. Night sweats. C. Weight loss greater than 10% within the prior 6 months. iii) Splenomegaly with inferior margin below the umbilical line. iv) Any one of the following cytopenia due to lymphoma:. A. Platelets \<100,000 cells/mm3 (100 x 109/L). B. Absolute neutrophil count (ANC) \< 1,500 cells/mm3 (1.5 x 109/L). C. Hemoglobin \< 10g/dL (6.25 mmol/L). v) Pleural or peritoneal serous effusion (irrespective of cell content). vi) Any compressive syndrome (for example, but not restricted to ureteral, orbital, gastrointestinal). Exclusion Criteria * Clinical evidence of transformed lymphoma by investigator assessment. * Follicular Large Cell as per WHO 5th classification or Grade 3b follicular lymphoma as per WHO 4th classification. * Participant has any significant medical condition, active infection, laboratory abnormality, or psychiatric illness that would prevent the participation in the study. * Other protocol-defined Inclusion/Exclusion criteria apply.

Study Info

Organization

Celgene


Primary Outcome

Number of participants who achieve complete metabolic response (CMR) as assessed by Lugano criteria 2014


Outcome Timeframe Up to approximately 12 months from participant randomization

NCTID NCT06425302

Phases PHASE2

Primary Purpose TREATMENT

Start Date 2024-08-30

Completion Date 2026-11-23

Enrollment Target 90

Interventions

DRUG Golcadomide

DRUG Rituximab

DRUG Cyclophosphamide

DRUG Doxorubicin

DRUG Vincristine

DRUG Prednisone

DRUG Bendamustine

Locations Recruiting

Local Institution - 0152

United States, Alabama, Birmingham


Alaska Oncology and Hematology

United States, Alaska, Anchorage


Mayo Clinic in Arizona - Phoenix

United States, Arizona, Phoenix


Local Institution - 0190

United States, Arizona, Tucson


Local Institution - 0035

United States, California, San Francisco


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