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A Phase 3 Randomized Clinical Study of MK-4280A (Coformulated Favezelimab [MK-4280] Plus Pembrolizumab [MK-3475]) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (KEYFORM-008)


Description

Researchers are looking for a way to treat classical Hodgkin lymphoma (cHL) that is relapsed (the cancer has come back after treatment) or refractory (current treatment has stopped working to slow or stop cancer growth). Researchers want to learn if people who receive coformulated favezelimab/pembrolizumab (MK-4280A) live longer without the cancer getting worse compared to those who receive chemotherapy.

Trial Eligibility

Inclusion Criteria: * Has histologically confirmed diagnosis of classical Hodgkin lymphoma (cHL) that is 2-fluorodeoxyglucose-avid (FDG-avid). * Has relapsed (defined as disease progression after most recent therapy) or refractory (defined as failed to achieve CR or PR to most recent therapy) cHL and exhausted all available treatment options with known clinical benefit. * Has progressed on treatment with an anti-PD-(L)1 monoclonal antibody (mAb) administered either as monotherapy or in combination with other checkpoint inhibitors or other therapies. * Submits an archival (≤5 years) or newly obtained tumor tissue sample which has not been previously irradiated. Exclusion Criteria: * Diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy. * History of central nervous system (CNS) metastases or active CNS involvement. * Has an active autoimmune disease that has required systemic treatment in past 2 years except replacement therapy. * History of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease. * Has an active infection requiring systemic treatment. * History of hemophagocytic lymphohisticytosis. * Has an active seizure disorder that is not well controlled. * Has clinically significant (ie, active) cardiovascular disease. * Received prior systemic anticancer therapy including investigational agents within 4 weeks before randomization. * Received prior radiotherapy within 2 weeks of start of study intervention or radiation related toxicities requiring corticosteroids. * Has not adequately recovered from major surgical procedure. * Known additional malignancy that is progressing or has required active treatment within the past 3 years. * History of human immunodeficiency virus (HIV). * Has had an allogeneic hematopoietic stem cell or solid organ transplantation within the last 5 years.

Study Info

Organization

Merck Sharp & Dohme LLC


Primary Outcome

Progression Free Survival (PFS) per Lugano Response Criteria as Assessed by Blinded Independent Central Review (BICR)


Outcome Timeframe Up to approximately 43 months

NCTID NCT05508867

Phases PHASE3

Primary Purpose TREATMENT

Start Date 2022-10-18

Completion Date 2027-05-25

Enrollment Target 360

Interventions

BIOLOGICAL favezelimab/pembrolizumab

DRUG bendamustine

DRUG gemcitabine

Locations Recruiting

The University of Arizona Cancer Center - North Campus ( Site 2216)

United States, Arizona, Tucson


UCLA Hematology/Oncology - Santa Monica ( Site 2208)

United States, California, Los Angeles


Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site

United States, California, Torrance


Moffitt Cancer Center ( Site 2200)

United States, Florida, Tampa


University of Kentucky Chandler Medical Center ( Site 2201)

United States, Kentucky, Lexington


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