Hello Everyone, I have a double hit high risk MM with 17P deletion and 1Q amplification. I am going thru induction therapy, 2nd line, switched to Isa-KRD last 2 cycles. Before that I was on Isa-VRD for 4 cycles and developed severe eye sties. My STEM cell transplant is expected to take place around Fed 2024. When I started my induction my free light chain Kappas were around 1950 mg/L and M protein was at 2.3 g/dL. I got a really good response intially after being on Velcade for 2 cycles. My free light chain Kappas decreased to 436 mg/L and M protein went down to 1.7 g/dL. The numbers plateaued after that for 2 cycles. The numbers increased when I was put off of Velcade for a month. Since starting new regimen with Kyprolis, the numbers fluctuated in both direction intially but now my ight chain Kappas are at 222 mg/L and M protein wis at 1.0 g/dL. The M protein is at 1.0 g/dL for the last 5 weeks. I am reaching out to you all with 3 questions: 1. Does my numbers look like they are improving as expected? 2. What were your numbers before SCT? 3. Are these numbers expected to be normalize before SCT? Thank you so much for your time!