Here, we summarize a new study presented at the European Hematology Association (EHA) congress by Dr. Julio Chavez from the Moffitt Cancer Center. He discusses the treatment with a new agent called golcadomide (also known as golca, by BMS) in combination with rituximab for patients with follicular lymphoma who progressed or lost response to previous therapies (relapsed and refractory).
Golcadomide is part of a new generation of drugs that are classified as cereblon E3 ligase modulators or CELMoDs. It is a type of medication that targets the protein cereblon, which has a role in adjusting the immune response to cancer.
Similarly to immunomodulators (IMiDs), CELMoDs are also oral medications but are considered to have improved efficacy and tolerability, making them a promising option for patients who can't tolerate IMiDs like lenalidomide or whose lymphoma become refractory.
Previous studies have shown an effective safety profile and also indicate that the mechanisms of action of golcadomide can be more effective when combined with the standard of care, rituximab-based therapy.
The side effects reported so far with golcadomide are not new to lymphoma physicians; however, for some patients, it meant they had to reduce or discontinue their treatment with golcadomide. The most common side effects are:
HealthTree had the opportunity to interview Dr. Julio Chavez, who summarized for us the latest data he presented about golcadomide in follicular lymphoma.
This is an ongoing Phase 1/2 clinical trial recruiting patients with relapsed/refractory follicular lymphoma who had been treated with at least 2 prior therapies. You can find all the information about this trial and the hospitals that are still recruiting participants here (NCT03930953).
In summary, golcadomide induces deep and sustained remissions in patients with follicular lymphoma who had already been treated with most of the available treatments and can potentially be more efficacious when combined with rituximab. This study is ongoing and recruiting more participants to confirm these findings.
Join the HealthTree community and stay updated with the current and upcoming treatments for follicular lymphoma with our newsletter and patient webinars.
Subscribe to the follicular lymphoma newsletter
Sources:
Here, we summarize a new study presented at the European Hematology Association (EHA) congress by Dr. Julio Chavez from the Moffitt Cancer Center. He discusses the treatment with a new agent called golcadomide (also known as golca, by BMS) in combination with rituximab for patients with follicular lymphoma who progressed or lost response to previous therapies (relapsed and refractory).
Golcadomide is part of a new generation of drugs that are classified as cereblon E3 ligase modulators or CELMoDs. It is a type of medication that targets the protein cereblon, which has a role in adjusting the immune response to cancer.
Similarly to immunomodulators (IMiDs), CELMoDs are also oral medications but are considered to have improved efficacy and tolerability, making them a promising option for patients who can't tolerate IMiDs like lenalidomide or whose lymphoma become refractory.
Previous studies have shown an effective safety profile and also indicate that the mechanisms of action of golcadomide can be more effective when combined with the standard of care, rituximab-based therapy.
The side effects reported so far with golcadomide are not new to lymphoma physicians; however, for some patients, it meant they had to reduce or discontinue their treatment with golcadomide. The most common side effects are:
HealthTree had the opportunity to interview Dr. Julio Chavez, who summarized for us the latest data he presented about golcadomide in follicular lymphoma.
This is an ongoing Phase 1/2 clinical trial recruiting patients with relapsed/refractory follicular lymphoma who had been treated with at least 2 prior therapies. You can find all the information about this trial and the hospitals that are still recruiting participants here (NCT03930953).
In summary, golcadomide induces deep and sustained remissions in patients with follicular lymphoma who had already been treated with most of the available treatments and can potentially be more efficacious when combined with rituximab. This study is ongoing and recruiting more participants to confirm these findings.
Join the HealthTree community and stay updated with the current and upcoming treatments for follicular lymphoma with our newsletter and patient webinars.
Subscribe to the follicular lymphoma newsletter
Sources:
about the author
Lisa Foster
Lisa Foster is a mom of 3 daughters, a puzzle lover, writer and HealthTree advocate. She believes in the mission of the foundation and the team that builds it forward. She calls Houston, Texas home.
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