What can be used to treat myeloma bone disease?

What can be used to treat myeloma bone disease? The best treatment for myeloma bone disease is anything that kills myeloma cells. Zometa and Xgeva decrease the risk of fracture and to decrease risk of side effects of those two drugs, the low calcium levels, you can use vitamin D and oral calcium supplementation. Bisfosfinates and rank ligand inhibitors both are kind of equally effective. There's one trial showing that those rank ligand inhibitors, the stenosumab, which is a newer drug, seems to have a positive benefit until a disease comes back. We call it progression-free survival. The bisphosfinates are around for tens of years. I think both have their place, especially in patients with kidney dysfunction. They should rather use the stenosumab. All the others that are on bisphosfinates and tolerate them, well, they should stay with that. They are not research driven. So that's what's helping. Also the progesterone inhibitors, the first data was for the botasomib. That's helping to regrow bone. There are also new drugs not approved for myeloma and not tested in myeloma, but there are new drugs in osteoporosis. They might come to myeloma eventually. So this is on the drug side. I think that physical exercise also helps because we know, for example, the astronauts coming back from outer space, they also lose bone mass and they do exercise to increase their bone strength. And I think myeloma patients might have a similar effect. Again, be very careful. Talk to your doctor, especially to your orthopedist, if you can do any exercise. I think those are the things that you as a patient can do.