Should MGUS be treated?

Should MGUS be treated?

My answer right now, no, I mean, there's no evidence that we should be treating it. There are no data to support that, and as the majority of the patients will live their life and die from something else. So I don't think there is a treatment for MGUS. I think one day we may understand the subset of patients at high risk for progression, and we may be able to find a therapy that is safe, effective, and limited. But we don't have that today. So I think the answer is no treatment for MGUS today. We don't think that MGUS should be treated. However, it's an interesting question. Could doctors potentially prevent progression to myeloma from happening by very early interception at the MGUS stage? At the MGUS stage, that will really develop myeloma? So I have a lot of points here. Not all MGUS should be treated, but there is a subgroup of MGUS that may actually dissolve myeloma in the next ten years. Should we develop a vaccine therapy? Should we think of some early intervention, something that you can really get rid of the disease at an early time point? And this is where we're thinking of vaccine therapies, really interesting ideas of how to truly prevent the disease from progressing.