Can you go over the history of novel/new drugs?

[Music] can you go over the history of novel or new drugs another thing which is great about myelomas at least we have new drugs so before new drugs trading my alone was like winning protects and then would come then all of a sudden five coming once so this is from a fellow named Khalid Health hush me he's from Oman and he told me this and I thought that's that's really good because we now have all these new drugs and we don't know exactly how to sequence them all which is a good problem to have but it can be a little frustrating when you're trying to figure it out so for example this is what we used to do and this is back in the 1950s when Malcolm was first introduced it's now used in high dose but back then it was use distant world drug it was then combined with prednisone and then it was given in very high dose that was the first time in England and then this regimen called dad was developed well that the V does not stand for Velcade or portes MIT stands for being Christine for those who of us who are old enough would remember using this because this was like a big step forward for melon and prednisone it was developed by dr. Barlow he at Arkansas who has continued to develop a lot of things he's now at Mount Sinai everybody says he is a bit aggressive he's incredibly aggressive but he he has really pushed the field now sometimes they have to modulate that aggressiveness but but it has led to some major advances and then we just used our using high-dose Dex you didn't need the adriamycin and vincristine but it's still as you know fairly toxic Texas methadone is no fun and then he was the one who really pushed autologous transplant high-dose therapy with stem cells support using peripheral but the French and the and dr. Barr Logie and Anderson and then it Arkansas did that and then the bisphosphonates came out which really mitigate or decreased the toxicity of bone problems then the image were developed and I don't have time but his he tells a very interesting story of how polygamy was first used it was Riis and rut good result it was thought that would inhibit blood vessel growth myeloma has thought to have caused increased blood vessel growth in the marrow so it was tried out and then it turns out it worked it turns out it works for a variety of reasons and then the derivatives lanolin amide and pomalidomide and now there are a whole slew they changed the name it used to be these were called ament's now they're called cell mods there's so modulatory agents of the Sarabande ligase it's a long term it's a it's for branding purposes I'm pretty sure and they have another one cc 485 which is also in clinical development so there's gonna be a whole slew of these that are coming along which have different effects then the party of some inhibitors were also big advance or Tesman was the first in-class carfilzomib and then X azimuth and then there's others that are in clinical trial now others beyond this then we have the H Jack inhibitor the pan H Tech inhibitor panobinostat was approved with the bortezomib and steroids there's another one called 241 which is a selective one that's in clinical trial the monoclonal a dove big advance eel oh and Dara in particular but there's a whole slew of them that are in developed development some some effect this one was first reported for Susan Trudel from Toronto it's a monoclonal but it's got a poison on it so it gets like it's like a Trojan horse it gets binds to sell up taking them boom it kills the cell because there's a poison on