BETA - Is there a difference in how quickly light chain myeloma responses are detected in monitoring as opposed to heavy chain responses?

Regarding light chain myeloma versus heavy chain myeloma and the responses, my experience has been that light chains change more rapidly than heavy chains. So if you've got really high free light chain production, you're probably going to see those levels either go up or go down faster than you're going to see the heavy chain. That's not always the case. There are some people with myeloma where the heavy chain really is the predominant thing. And it just takes a lot longer for the big heavy chain to clear than it does for the light chains to clear. But that doesn't necessarily indicate what's going on with the myeloma cells themselves. All that that has to do with is what they're making. And I would say that the more important thing, I mean, we love to see the numbers going down, but the more important thing is, is the cancer growing? Is the cancer shrinking? Is the cancer staying stable? And the numbers help us to figure that out. But it's not a race to get the numbers the lowest that they can be. The goal is to keep it under control as long as possible. So yes, there's a little bit of a difference, but in the end, you know, there's no big difference between the two types. It's just how quickly the numbers change.