Hi, I'm Urvi Shah, a hematologist and oncologist on the Myeloma Service at Memorial Sloan Kettering Cancer Center. And I wanted to discuss our study on monoclonal gemopathy of unknown significance and the risk of development in relation to dietary risk factors. The study was done as a collaboration between Roswell Park and Memorial Sloan Kettering Cancer Center. With the expertise of Dr. Susan McCann, a dietitian at Roswell Park, as well as Janine Joseph who led the study. What we did in the study was look at cases and controls through the NHANES data set. What we found was we had about 300, approximately 300 cases of MGUS and then we matched controls with very similar characteristics about 4 is to 1, so we had about 1200 controls. What we looked at was different dietary foods with a 24 hour recall. So all participants on the study had answered a 24 hour dietary survey to let us know in the NHANES data set of what they had eaten so far. Then we looked at risk of certain food groups and the risk of development of MGUS. What we saw is that foods like whole grains, vegetables, fruits were associated with about a 20 to 30% reduced risk or odds of development of MGUS. Foods such as sugar sweetened beverages and whether artificially sweetened or sugar sweetened were associated with about a 30 to 50% increased risk of development of MGUS. Suggesting that dietary factors may be one of the many factors that play a role in MGUS development.
