What is syngenetic? (the twin type of Allo)

What is syngenetic transplant? (the twin type of allo)

If you're one of the lucky people

in the world who have a identical twin,
so I guess it's the number.

I think it's about one in 80
that is a twin pregnancy.

So if you have myeloma
and you happen to have a twin,

that is an exceptionally rare
circumstance.

In my practice,
I have only done it four times.

We did a CIBMTR study a decade ago
that we found about 80 patients

in the country who had a twin transplant
and turns out that if you have a twin,

the twin should be a donor
because twin transplants

are basically allo transplants
because you don't get an immune effect.

The twins immune system
is exactly your immune system.

So if your myeloma could find a way past
your own immune system, it will be fine.

If they pass your twins
immune system, too.

But you're getting a very clean graft
from the twin

in that the cells that we collect in
the twin are guaranteed

to be clean of myeloma
and we use those cells for the transplant.

So it is as simple
as doing an autologous transplant, but

it tends to give you a longer progression
free survival from the transplant.

So it is rare, but it is

the donor to choose
if you happen to have a twin.