Hello.
I'm Yoshinobu Konishi from Dana-Farber Cancer Institute.
In this ASH meeting, we present the new data using the spatial profiling of the bone marrow immune microenvironment.
Bone marrow is a place we create the blood, red blood cells, white blood cells, and platelets. But also this is the place for myeloma cells growth.
In the bone marrow microenvironment, there is a fight of immune cells. They are fighting against bone marrow microenvironment, myeloma cell.
In the bone marrow, host immune cells walk together to fight or support myeloma cells. So we want to understand the cell to cell interactions within the bone marrow. What happens? They are doing better.
In the prior studies people use delicate samples from bone marrow. It provides nice insights in the detail of their understanding of disease process. However, they lack spatial information as they under the present some important cells like lipid cells and macrophages. They eat a lot of myeloma cells.
To overcome this issue, we developed a new methodology spatial profiling, using highly specific mass site battery based imaging. And we applied this technology to the patient who received CAR-T therapy.
And our final results spatially organized immune features in the bone marrow can predict clinical outcomes like survival or development of the side effect.
I believe this technology can provide better insights about intercellular interaction within the bone marrow. And this will help us to better stratify patients who get better prognosis after receiving CAR-T.
And also this will provide a better opportunity for us to find the cells as a directable target.
HealthTree • December 20, 2024