What is autologous NK cell therapy? Well, it’s a product or a cells that were discovered in at KI at Karolinska Institute and the tradition is to do research on that. One of my lab buddies he discovered a way to to expand them. So instead of having one cell per 100 he expanded them 1000 folds by just culturing them in three weeks, he asked me.
Both him and Professor Gosta got them to write a protocol to treat myeloma patients on that, and we performed the Phase one study. It's five years now, and it was not an effect study. It's not a efficacy study. It was a safety study. And we could see that all patient that was treated had some response. So we’re expanding that idea and doing a Phase two study in combination with the antiCD 38 antibody as maintenance treatment after autologous bone marrow transplantation.
We usually collect them at diagnosis when the patient get his his or her diagnosis of myeloma. We ask them to donate to themselves, that one unit of blood from that unit of blood, we isolate the NK cells and culture them and freeze them down until as it is today is in clinical trials. But hopefully in the future we can.You can donate your cells even. The idea could be that you as a patient can donate 1 unit blood your cells, you can isolate the NK cells, culture them, can isolate the T cells and freeze them down. We have evidence that these cells can stay in the freeze 20 years.
HealthTree • November 30, 2022