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Relapsed and Refractory MM Treatment
1. What is relapsed myeloma and refractory myeloma? Video
2. What is progressive disease? Is it the same as relapse? Video
3. What is a Biochemical vs Clinical Relapse? Video
4. What are the cycles of relapse and remission in myeloma? Video
5. Why do drugs stop working? Video
6. Do individuals become refractory to a given drug or an entire class of drugs? Video
7. What testing should be done at relapse? What is restaging? Video
8. What are the goals of treatment at relapse? Video
9. With relapsed myeloma, when should you modify current therapy change dosage? Video
10. What are the NCCN Treatment Guidelines? What strategy should be used in selecting a therapy? Video
11. Why is it important to be consulting with a myeloma specialist at relapse? Video
12. What treatments are available for first relapse with lenalidomide refractory disease? Video
13. What treatments should be considered in bortezomib/velcade refractory patients at first relapse? Video
14. What are some possible monoclonal antibodies combinations to consider at first relapse in multiple myeloma? (daratumumab, isatuximab, elotuzumab) Video
15. What are some newer therapies with different mechanisms of action to consider at first relapse? Video
16. What does it mean to be triple class refractory? Video
17. Is there a role for transplant if not used upfront or a second transplant at first relapse? Video
18. What is the role of genomics at relapse? Video
19. Are there any targeted approaches for specific genetic subsets that patients should ask about? Video
20. How do you decide on an appropriate treatment at relapse with so many to choose from? Video
21. When should a patient consider a clinical trial in relapse? Video
22. With so many options available, at what point should a patient consider getting a second opinion? Video
23. What treatments are available for patients with relapsed refractory myeloma who have received at least two prior lines of therapy but less than 4 lines of therapy? Video
24. What is meant by t-cell redirecting therapy? Video
25. Where should CAR-T cell therapy be positioned in the RRMM setting? Video
26. Where should bispecific antibodies be positioned in RRMM? Video
27. What factors should be considered when choosing between a CAR T cell therapy and a bispecific antibody therapy? Video
28. What is a BCMA-directed Therapy? What are some FDA approved BCMA-directed therapies? Video
29. Is there a role for conventional chemotherapy in the treatment of relapsed and refractory myeloma? Video
30. Will an allogeneic transplant ever be considered at relapse? Video
31. What are some promising investigational agents and novel therapies for relapsed/refractory patients? Video
32. What is the role of supportive care throughout relapsed and refractory myeloma management? Video
33. What is bone strengthening therapy? Video
34. What are some tips for coping with the fear of relapse? Video
35. What are the unmet needs and challenges in the relapsed/refractory myeloma setting? Video
36. How can HealthTree help with assessing treatment options at relapse? Video
37. What is Off-label Use of a Drug? Video
38. What is Considered a Line of Therapy? Video
39. What treatment options could patients who relapse after later line CAR-T cell therapy consider? early line CAR-T cell therapy? both CAR-T and BsAbs? Video
40. (Guest Lecture): Immunotherapies | Experts Discuss Relapsed/Refractory Myeloma, Amyloidosis Video
41. (Guest Lecture): Relapsed Refractory Multiple Myeloma - Krina Patel, MD, MSc | RT Irvine, CA Nov 5, 2022 Video
42. (Guest Lecture): Amyloidosis | Experts Discuss Relapsed/Refractory Myeloma, Amyloidosis Video
43. (Guest Lecture) When and How you Become Refractory to a Drug and How to Find the Best Next Treatment Video
44. (Guest Lecture): Emerging Treatments | Experts Discuss Relapsed/Refractory Myeloma, Amyloidosis Video
45. (Guest Lecture): September 2023 - Personalizing Options for Relapse/Refractory Patients Video
46. (Guest Lecture): October 2023 - Personalizing Therapy for Each Relapsed/Refractory Myeloma Patient Video
47. (Guest Lecture): March 2024 - The Bounty of Treatments for Early Relapsed Myeloma Video
48. (Guest Lecture): March 2024 - Exploring the Myeloma Toolbox Video
What is relapsed myeloma and refractory myeloma?
3 years ago
Lesson Description
Learn about relapsed and refractory myeloma in this video.