VEXAS syndrome

VEXAS syndrome is a recently identified inflammatory condition, primarily affecting older men, caused by a change in a gene called UBA1. This change leads to widespread inflammation, meaning your body's immune system causes irritation or swelling throughout the body. The condition often connects symptoms like skin rashes and fevers with issues in your bone marrow—the spongy tissue inside bones that makes blood cells—including conditions such as MDS or multiple myeloma. Understanding VEXAS can help explain seemingly unrelated symptoms and inform your treatment plan. This topic offers information and support to help you understand VEXAS syndrome and its impact on your health and daily life.