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The very exciting ALT-803 myeloma immunotherapy with Dr. Sarah Holstein, MD, PhD at Roswell Park
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Apple Podcasts
Youtube
Tell your musician friends to donate a song today on Songs For Life to help raise funds for multiple myeloma research! Dr. Sarah Holstein, MD, PhD, Roswell Park Cancer Institute Interview Date: September 19, 2014
Dr. Sarah Holstein describes a very exciting new immunotherapy that will open in a Phase I/II clinical trial shortly. This new drug called ALT-803 by Altor Bioscience was listed as one of the most exciting immunotherapy choices according to the NCI. In experiments in mice, it changed the immune system to kill myeloma cells and then trained the immune system with a memory to continue attacking it, even when more myeloma cells were injected. Dr. Holstein shares the details of how this new therapy works. She also discusses her research to "choke" myeloma cells with their own product by leveraging the secretory nature of myeloma (the production of the M-spike). Additionally, she shares three strategies to overcome bortezomib resistance - 1) using HDAC inhibitors, 2)Using new heat shock proteins and 3) Manipulating the bone marrow microenvironment. There is much to learn in this excellent show. The live mPatient Myeloma Radio podcast with Dr. Sarah Holstein, MD, PhD,
Tell your musician friends to donate a song today on Songs For Life to help raise funds for multiple myeloma research! Dr. Sarah Holstein, MD, PhD, Roswell Park Cancer Institute Interview Date: September 19, 2014
Dr. Sarah Holstein describes a very exciting new immunotherapy that will open in a Phase I/II clinical trial shortly. This new drug called ALT-803 by Altor Bioscience was listed as one of the most exciting immunotherapy choices according to the NCI. In experiments in mice, it changed the immune system to kill myeloma cells and then trained the immune system with a memory to continue attacking it, even when more myeloma cells were injected. Dr. Holstein shares the details of how this new therapy works. She also discusses her research to "choke" myeloma cells with their own product by leveraging the secretory nature of myeloma (the production of the M-spike). Additionally, she shares three strategies to overcome bortezomib resistance - 1) using HDAC inhibitors, 2)Using new heat shock proteins and 3) Manipulating the bone marrow microenvironment. There is much to learn in this excellent show. The live mPatient Myeloma Radio podcast with Dr. Sarah Holstein, MD, PhD,
Sarah Holstein, MD, PhD
Jennifer Ahlstrom