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A Look into the 2025 Multiple Myeloma Landscape with Robert Orlowski, MD, PhD, MD Anderson Cancer Center
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The year 2025 brings new promise in multiple myeloma with a wide variety of treatment options avaiable for both newly diagnosed and relapsed/refractory patients. Learn about the progress being made and the very latest in determining risk at diagnosis, strategies for smoldering myeloma patients, optimal treatments for newly diagnosed patients, things to consider at first relapse and beyond. Dr. Robert Orlowski will review advances in CAR T therapies, bispecific antibodies, targeted therapies, combination approaches and clinical trials to watch as the research continues advancing at a rapid pace in myeloma.
Dr. Robert Orlowski joins the HealthTree for Multiple Myeloma Podcast to share the recent announcements from the American Society of Hematology meeting and what we have to look forward to in 2025. He shares new approaches for high risk smoldering myeloma that may include near-term FDA approvals for daratumumab and the triple combination of isatuximab/lenalidomide/dex. He also describes CAR T approaches in smoldering myeloma and the pros and cons of that treatment approach.
He describes the importance and data showing that quad therapies are the new way to go for newly diagnosed patients. He shares many updates for relapsed and refractory myeloma patients including the use of maintenance therapy (with a two-drug combination with daratumumab and lenalidomide), new bispecific antibody results for teclistamab, cevostamab and talquetamab and the importance of having multiple targets for immunotherapies. He shares how MRD is being used as a new clinical trial endpoint, how blenrep (an antibody drug conjugate) is likely to make a comeback, and how new CART therapies like anito-cel are looking promising.
The show is full of gems that patients will want to know like why you may be able to stop 24-hour urine testing, why new monocloncal protein testing like mass spectometry is more accurate, the infection prevention (and lengthening of life) from IVIG, lower rates of cytokine release syndrome (CRS) when CAR T is given after stem cell transplant and how the new drug class called CELMods can actually re-activate T cells.
This is a show not to be missed by one of the top myeloma experts in the world.
Jenny Ahlstrom
Robert Orlowski, MD, PhD