A Look into the 2025 Multiple Myeloma Landscape with Robert Orlowski, MD, PhD, MD Anderson Cancer Center
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Apple Podcasts
YoutubeDr. Robert Orlowski joins the HealthTree for Multiple Myeloma Podcast to share the recent announcements from the American Society of Hematology meeting and what we have to look forward to in 2025. He shares new approaches for high risk smoldering myeloma that may include near-term FDA approvals for daratumumab and the triple combination of isatuximab/lenalidomide/dex. He also describes CAR T approaches in smoldering myeloma and the pros and cons of that treatment approach.
He describes the importance and data showing that quad therapies are the new way to go for newly diagnosed patients. He shares many updates for relapsed and refractory myeloma patients including the use of maintenance therapy (with a two-drug combination with daratumumab and lenalidomide), new bispecific antibody results for teclistamab, cevostamab and talquetamab and the importance of having multiple targets for immunotherapies. He shares how MRD is being used as a new clinical trial endpoint, how blenrep (an antibody drug conjugate) is likely to make a comeback, and how new CART therapies like anito-cel are looking promising.
The show is full of gems that patients will want to know like why you may be able to stop 24-hour urine testing, why new monocloncal protein testing like mass spectometry is more accurate, the infection prevention (and lengthening of life) from IVIG, lower rates of cytokine release syndrome (CRS) when CAR T is given after stem cell transplant and how the new drug class called CELMods can actually re-activate T cells.
This is a show not to be missed by one of the top myeloma experts in the world.
Jenny Ahlstrom
Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of the HealthTree Foundation.
Robert Orlowski, MD, PhD
Robert Z. Orlowski, M.D., Ph.D., is Director of Myeloma, and Professor of Medicine in the Departments of Lymphoma/Myeloma and Experimental Therapeutics, where he is board-certified in medical oncology. Dr. Orlowski earned his doctoral degree in molecular biophysics and biochemistry from Yale University and his medical degree from the Yale University School of Medicine. He completed his internship and residency in Internal Medicine at Barnes Hospital at the Washington University in St. Louis School of Medicine. After his fellowships in Hematology and Medical Oncology at John Hopkins Sidney Kimmel Comprehensive Cancer Center, he joined the faculty at University of North Carolina in Chapel Hill. Following that, Dr. Orlowski accepted a position at The University of Texas MD Anderson Cancer Center in 2007 to lead the Myeloma Section in the Department of Lymphoma/Myeloma. His research interests include pathobiology of, novel therapeutic targets and mechanisms of drug resistance in myeloma which are documented in hundreds of scientific articles, book chapters, and presentations at conferences. Dr. Orlowski is an investigator on numerous clinical trials, and appointed Myeloma Committee Chair for SWOG.
