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The Hidden Extent of Smoldering Myeloma and a Vaccine for Smolderers with Dr. Ajay Nooka, MD
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Apple Podcasts
YoutubeDr. Nooka shares some surprising statistics about the number of people living with smoldering myeloma, that it could be as large as 400,000 whereas only 25,000 new myeloma cases are diagnosed per year. He notes that risk-stratifying smoldering myeloma patients is key to finding the best outcomes. He describes how he diagnoses and approaches treatment for a smoldering myeloma patient and shares that today's risk stratification in smoldering myeloma is based today on three key clinical features and not on genetic features. Dr. Nooka describes a new vaccine by OncoPep now being used in early clinical trials with lenalidomide for smoldering myeloma patients. The vaccine targets three proteins including CD138, CS1 and XBP1 and participants have to be tested as HLA2 positive. He explains the difference between preventative vaccines and treatment vaccines and suggests that the tumor burden has to be low in order for them to work. He notes that using lenalidomide in addition to the vaccine appears to boost the immune system and give the vaccine greater impact. The Myeloma Crowd Radio Show with Dr. Nooka
Dr. Nooka shares some surprising statistics about the number of people living with smoldering myeloma, that it could be as large as 400,000 whereas only 25,000 new myeloma cases are diagnosed per year. He notes that risk-stratifying smoldering myeloma patients is key to finding the best outcomes. He describes how he diagnoses and approaches treatment for a smoldering myeloma patient and shares that today's risk stratification in smoldering myeloma is based today on three key clinical features and not on genetic features. Dr. Nooka describes a new vaccine by OncoPep now being used in early clinical trials with lenalidomide for smoldering myeloma patients. The vaccine targets three proteins including CD138, CS1 and XBP1 and participants have to be tested as HLA2 positive. He explains the difference between preventative vaccines and treatment vaccines and suggests that the tumor burden has to be low in order for them to work. He notes that using lenalidomide in addition to the vaccine appears to boost the immune system and give the vaccine greater impact. The Myeloma Crowd Radio Show with Dr. Nooka
Ajay Nooka, MD, MPH, FACP
Jennifer Ahlstrom