This looks promising https://myelomaresearchnews.com/news/fda-approves-sarclisa-regimen-first-line-treatment-myeloma/

I did a autologous stem cell transplant, three weeks ago. I was discharged from hospital and I'm struggling with fatigue 😩. Can you kindly advise on what to use

Is m spike called by other names in a MM panel

Open question to anyone, I have read that stem cell transplants are not as effective as once thought, and only for last resort treatment. Is this based on new research or just an opinion floating out there???

Hi everyone, I am a 35 yr old F. In 2022 after doing routine bw, my family MD found M spike of 10 g/L (I am Canadian) with a kappa of 18 mg/L and lambda 52 mg/L. FLC ratio within normal range. My other bw were normal. I was told I had mgus and the plan was to do routine bw yearly. In 2023, my m spike increased to 11.9 g/L and kappa 24mg/L and lambda 66 mg/L. I have since been following a hema/onc doctor. Now in 2024, my numbers doubled! My lambda is 130mg/L and kappa is 55 mg/L. My FLC ratio has stayed within the normal range. We are still waiting for the M protein to come back. My other bw is normal. I am freaking out, I have been under a tonne of stress because of my increasing numbers but my hematologist says everything is fine. I know a bone marrow biopsy would be helpful but my anxiety is too high I could not handle the stress of undergoing that and waiting for results. Has anyone who has been told they have mgus have this happen to them before where both kappa and lambda numbers increase. I am terrified and now I have to wait, yet again for my m protein to come back and I pray it has not increased as well. But if my kappa and lambda double, I am nervous my m protein would as well. I also see a naturopath who recommended some supplements that have been discussed in the group. Thank you in advance!

I am sure this has been discussed, but I can't find it... I am starting my treatment protocol in a month or so, consisting of the 4-drug regimine: Daratumumab, Bortezomib, Lenalidomide (Revlamid)and Dexamethasone (DVRd). What side effects can I expect?

I am scheduled for stem cell collection at the end of October. My doctor has suggested using Motixafortide (instead of Mozobil) for mobilization. Does anyone have any experience with this drug? I understand there are some unpleasant side effects.

Somewhat embarrassing self-image question... I've been on DRVd induction therapy since the end of March of this year and a cow lick on the back of my head has reappeared. It's been gone since I was in 3rd or 4th grade but now it's back. I'm wondering if this is just a normal aging thing (now 66yo) or if it's weird side effect of the drugs. Anyone else experienced anything like this?

A phase III study is open comparing a new drug called mezigdomide (CC-92480), carfilzomib and dexamethasone vs. carfilzomib and dexamethasone. Mezigdomide is part of a new class of drugs called CELMoDs. Study participants who have relapsed or refractory myeloma, at least one prior line of therapy (that included either lenalidomide or 2 cycles of an anti-CD28 monoclonal antibody) are welcome to join. Learn more: https://www.bmsclinicaltrials.com/us/en/clinical-trials/NCT05552976?cid=s_2839275

Good morning. I have a patient that I'm chatting with. She had a donor stem cell transplant. She now feels as if she has developed allergies and wonders if it is possible to have gotten them from her donor cells? Has anyone heard if this is possible?