Alexander Edward Perl, MD, MS

location_city University Of Pennsylvania Abramson Cancer Center

Specialities: Myelodysplastic Syndromes, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, Chronic Myeloid Leukemia

Spoken languages: English

Clinical Expertise

Acute Myeloid Leukemia
Acute Lymphocytic Leukemia
Myelodysplastic Syndromes
Chronic Myeloid Leukemia

About

Dr. Alexander Perl is a member of the leukemia program in the Abramson Cancer Center and an Associate Professor in the Division of Hematology/Oncology at the Perelman School of Medicine at the University of Pennsylvania. His research focuses on molecularly-targeted therapeutics for acute leukemia. His principal expertise is in FLT3 inhibitors for AML and he has played a leading role in clinical trails of these agents. He also studies other agents targeting signal transduction, such as tyrosine kinase inhibitors for Ph-like ALL and inhibitors of oncogenic PI3K/AKT/mTOR signaling. His laboratory studies focus on phospho-specific flow cytometry of fixed, unfractionated blood and marrow as a method to quantify pharmacodynamic response to signal transduction inhibitors. He is additionally interested in preclinical drug screening in cellular and murine xenotransplantation models of acute leukemia.