Calaspargase pegol is an enzyme that targets the amino acid L-asparagine. Many leukemia cells, especially those in acute lymphoblastic leukemia (ALL), cannot make enough L-asparagine on their own and rely on it from the bloodstream. Calaspargase pegol breaks down L-asparagine into aspartic acid and ammonia, depleting its levels in the blood. This deprives leukemia cells of a critical nutrient, leading to their death while sparing most normal cells that can produce their own L-asparagine.

This medication is a pegylated form of L-asparaginase, meaning it is attached to a molecule called polyethylene glycol (PEG) to help it stay in the body longer and reduce the frequency of dosing. By maintaining low levels of asparagine in the blood for extended periods, calaspargase pegol helps maximize its anti-leukemic effect.

Calaspargase pegol

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Approved use in