Isotretinoin is a retinoid, which is a type of medication related to vitamin A. It works by reducing the size and activity of sebaceous (oil) glands in the skin, which leads to a decrease in sebum (oil) production. This helps to prevent the formation of acne lesions. Isotretinoin also affects the process of keratinization, which is the way skin cells mature and are shed. By normalizing this process, isotretinoin helps prevent clogged pores and reduces inflammation.

Although its primary use is for severe, recalcitrant nodular acne, isotretinoin's impact on cell growth and differentiation is why it has been studied in other conditions, including some cancers. However, for blood cancers, isotretinoin is not a standard treatment. Its mechanism of action involves influencing gene expression and cell differentiation, which is why it has been explored in research for certain types of leukemia, but it is not routinely used for these conditions.

Isotretinoin

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Approved use in