It's definitely something to talk to your doctor about actually at every stage of the disease course because in CLL we have clinical trials that are for patients who actually even before treatment some of these supportive care measures like prevention of infection, the immune system effects that might be available to you. Here at Memorial Sloan-Kettering for example we have clinical trials that are attempting to refine and even improve the standard of care for the initial treatment and then in the relapse setting there are patients who've had many treatments for their CLL and we have trials that are looking at new drugs for CLL really first in human trials first. So for CLL it really depends where you are in the disease course but a clinical trial could be appropriate for you if available at really any stage and that's what we really do in our CLL program here at Memorial Sloan-Kettering. And so I would say at any time talk to your doctor. Clinicaltrials.gov has a listing of the CLL trials and your doctor can discuss what the standard options for you are outside of a clinical trial which is always really important to know and then see if there's a clinical trial available no matter what really stage of the disease you're at.