Do high-risk patients do transplant immediately?

Do high-risk patients do transplant immediately? Transplantation is done and works best when the person has as little disease in their body as possible. So the strategy in patients who are going to undergo a transplant is still to get the disease in remission. And when we talk about remission, we mean that the blast count is below 5 percent, in other words, the bone marrow looks normal and the blood counts return to normal. So when the disease is in remission and the leukemia is at its lowest level, that's when transplant is going to work the best. In fact, we now have methods to measure small amounts of leukemia, so-called minimal residual disease or measurable residual disease. And we know that if you can get this down to the lowest possible level, the chance of a successful transplant is greater. So we'll treat the patient first to get them in remission and sometimes even give additional treatment to further reduce the amount of leukemia in their body and then do the transplant.