Weighing FLT3 Inhibitor Options with Dr. Jane Liesveld, University of Rochester
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The FLT3 gene mutation is the most common mutation seen in acute myeloid leukemia patients. It occurs in approximately 30% of adult patients with AML. FLT3 mutations have been harder to treat with poor outcomes, however, with combination therapies using targeted drugs such as FLT3 inhibitors, outcomes have greatly improved. The development of FLT3 inhibitors has progressed in recent years and there are currently two FDA-approved options - gilteritinib and midostaurin. There are also many additional FLT3 inhibitors in development such as crenolanib and quizartinib, which leads us to the question of which FLT3 inhibitor should be used for each person and when is the appropriate time to add it to treatment?
Join us live on June 29th at 2 PM EST to hear from Dr. Jane Liesveld from the University of Rochester who will discuss the different FLT3 inhibitor options currently available, as well as the ones in development. Dr. Liesveld will also share research with us from a clinical trial she is leading comparing midostaurin and crenolanib when given following induction and consolidation in newly diagnosed FLT3 positive patients.
During the show, Dr. Liesveld will discuss the differences between FLT3 inhibitor options and what has been learned from previous FLT3 inhibitor trials. Come learn all about the FLT3 mutation, FLT3 inhibitors and have the opportunity to directly ask Dr. Liesveld your questions.
Thank you to our episode sponsor, Abbvie.
Dr. Jane Liesveld
University of Rochester
Interview Date: June 29, 2022
The FLT3 gene mutation is the most common mutation seen in acute myeloid leukemia patients, occuring in up to 37% of adult cases. FLT3 mutations have historically been harder to treat with poorer outcomes, however, with combination therapies using targeted drugs such as FLT3 inhibitors, outcomes have improved. In this show, Dr. Jane Liesveld, an AML expert from the University of Rochester, shared with us the FLT3 inhibitor options currently available and in development, as well as research from several recent clinical trials exploring new FLT3 inhibitor drugs.
Thanks to Our Episode Sponsor
Kerith Amen
Jane Liesveld, MD