Reducing Relapse Risk After Transplant Using Jakafi With Gabriela Hobbs, MD, Massachusetts General Hospital
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Apple PodcastsAllogeneic stem cell transplantation is the only curative option for patients battling acute myeloid leukemia. However, a significant number of patients will relapse after transplant. Innovative research and therapies are needed in order to improve outcomes in AML patients.
The drug Jakafi (ruxolitinib), a kinase inhibitor, is being explored in a current phase 2 clinical trial, as it may help reduce the risk of relapse. Other therapies such as pre-emptive donor lymphocyte infusions, hypomethylating agents and FLT3 inhibitors combined with donor lymphocyte infusions, CAR T-cell and CAR-NK cells are some of the options being explored.
In this show, we were joined by Dr. Gabriela Hobbs with Massachusetts General Hospital who discussed the challenges that exist with stem cell transplants and some of the therapies that are being explored to reduce the risk of relapse. Dr Hobbs told us about her current clinical trial using Jakafi (ruxolitinib) after allogeneic stem cell transplant, which has also shown to be beneficial in reducing graft-versus-host disease (GVHD).
Thank you to our episode sponsor, Bristol Myers Squibb.
Gabriela Hobbs
Dr. Hobbs is a hematology-oncology physician who specializes in the care of patients with myeloproliferative neoplasms (MPN), chronic myeloid leukemia and leukemia. She is an active clinical researcher and lead the MPN research program at MGH; she has lead several clinical trials and participate in translational research for MPN. In addition, Dr. Hobbs is the clinical director for the adult leukemia service at MGH. Dr. Hobbs strives to provide compassionate care for each patient and their family and works to tailor therapy to meet each patient's individual needs.
Kerith Amen
Kerith joined HealthTree Foundation as a Community Co-Director for AML in 2022. She is a mother to a spirited eight-year-old daughter, Adair, and their beloved rescue, Violet. She lost her best friend and husband, Rob, to AML in March 2018. Kerith wishes she had a resource such as HealthTree for AML during Rob’s illness. She is a strong supporter of HealthTree's mission. She hopes that by sharing her experience, she may help other patients and caregivers navigate an AML diagnosis.
