Phase 1 Therapy With Manufactured Autologous T-Cells Expressing a Second Generation Chimeric Antigen Receptor (CAR) for Treatment of T-Cell Malignancies Expressing CD5 Antigen

Description

Patients eligible for this study have a type of blood cancer called T-cell leukemia or lymphoma (lymph gland cancer). The body has different ways of fighting infection and disease. No one way seems perfect for fighting cancers. This research combines two different ways of fighting disease, antibodies and T cells. Antibodies are proteins that protect the body from bacterial and other diseases. T cells, or T lymphocytes, are special infection-fighting blood cells that can kill other cells including tumor cells. Both antibodies and T cells have shown promise treating patients with cancers, but have not been strong enough to cure most patients. T lymphocytes can kill tumor cells but there normally are not enough of them. Some researchers have taken T cells from a person's blood, grown more in the lab then given them back to the person. In some patients who've had recent bone marrow or stem cell transplant, the number of T cells in their blood may not be enough to grow in the lab. In this

Trial Eligibility

Procurement Inclusion Criteria Referred patients (Group A) or their previous HSCT donors (Group B) will initially be consented for procurement of blood for generation of the transduced ATL. Patient eligibility criteria at this stage include: 1. Diagnosis of recurrent T-cell acute lymphoblastic leukemia (T-ALL), T-cell acute lymphoblastic lymphoma (T-LLy), or T-non-Hodgkin lymphoma (T-NHL, including Angioimmunoblastic T-cell lymphoma (AITL), Enteropathy-associated T-cell lymphoma (EATL), Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), Peripheral T-cell lymphoma (PTCL) NOS, Anaplastic large cell lymphoma (ALCL), Adult T-cell leukemia/lymphoma, T cell prolymphocytic leukemia with symptomatic disease, Extranodal NK/T cell lymphoma, Mycosis fungoides/ Sezary Syndrome Stage IIB or higher) AND Group A (auto arm): Transplant naïve or relapsed post-allogeneic HSCT OR Group B (allo arm): Relapsed post-allogeneic HSCT with previous HSCT donor from whom allogeneic MAGENTA CAR T cells can be manufactured AND * Suitable for allogeneic hematopoietic stem cell transplant (HSCT) with confirmation of an identified eligible allo-HSCT donor by FACT accredited institution * Confirmation that the center plans to proceed with transplant if CD5.CAR treatment induces a complete remission. 2. CD5-positive tumor (result can be pending at this time). \> 50% CD5 + blasts by flow cytometry or immunohistochemistry (tissue) assessed by a CLIA certified Flow Cytometry/Pathology laboratory. 3. Age less than or equal to 75 years old. NOTE: The first six (6) patients treated on the study will be adults (\>18 yrs of age). 4. Hgb greater than or equal to 7.0 (can be transfused) 5. Life expectancy greater than 12 weeks 6. If pheresis required to collect blood: * Creatinine \<1.5 × upper limit normal * AST \<1.5 × upper limit normal * PT and APTT \<1.5 × upper limit normal 7. Patients must have an available partially-HLA matched allogeneic EBV-specific T cell line on a BCM IRB approved protocol which can be used as treatment in the event of uncontrolled EBV reactivation 8. Informed consent explained to, understood by and signed by patient/guardian. Patient/guardian given copy of informed consent. Procurement Exclusion Criteria: 1. Active infection requiring antibiotics. 2. Active infection with HIV. 3. Clinically significant viral infection or uncontrolled viral reactivation of EBV, CMV, Adv, BK-virus, or HHV-6. 4. History of other cancer (except non-melanoma skin cancer or in situ breast cancer or cervix cancer) unless the tumor was successfully treated with curative intent at least 2 years before trial entry. Treatment Inclusion Criteria: 1. Diagnosis of recurrent T-cell acute lymphoblastic leukemia (T-ALL), T-cell acute lymphoblastic lymphoma (T-LLy), or T-non-Hodgkin lymphoma (T-NHL, including Angioimmunoblastic T-cell lymphoma (AITL), Enteropathy-associated T-cell lymphoma (EATL), Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), Peripheral T-cell lymphoma (PTCL) NOS, Anaplastic large cell lymphoma (ALCL), Adult T-cell leukemia/lymphoma, T cell prolymphocytic leukemia with symptomatic disease, Extranodal NK/T cell lymphoma, Mycosis fungoides/ Sezary Syndrome Stage IIB or higher) AND Group A (auto arm): Transplant naïve or relapsed post-allogeneic HSCT OR Group B (allo arm): Relapsed post-allogeneic HSCT with previous HSCT donor from whom allogeneic MAGENTA CAR T cells can be manufactured. AND * Suitable for allogeneic hematopoietic stem cell transplant (HSCT) with confirmation of an identified eligible allo-HSCT donor by FACT accredited institution * Confirmation that the center plans to proceed with transplant if CD5.CAR treatment induces a complete remission. 2. Age less than or equal to 75 years old. NOTE: The first six (6) patients treated on the study will be adults (\>18 yrs of age). 3. Bilirubin less than 3 times the upper limit of normal. 4. AST less than 5 times the upper limit of normal. 5. Estimated GFR \> 60 mL/min. 6. Pulse oximetry of \> 90% on room air 7. Karnofsky or Lansky score of greater than or equal to 60%. 8. Recovered from acute toxic effects of prior chemotherapy at least one week before entering this study. 9. ≥ 60 days post-allogeneic HSCT at time of treatment. 10. Life expectancy of greater than 12 weeks. 11. Patients must have an available partially-HLA matched allogeneic EBV-specific T cell line on a BCM IRB approved protocol which can be used as treatment in the event of uncontrolled EBV reactivation. 12. Sexually active patients must be willing to utilize one of the more effective birth control methods during the study and for 6 months after the study is concluded. The male partner should use a condom. 13. Informed consent explained to, understood by, and signed by patient/guardian. Patient/guardian given copy of informed consent. Treatment Exclusion Criteria: 1. Currently receiving any investigational agents or having received any tumor vaccines within the previous 6 weeks. 2. History of hypersensitivity reactions to murine protein-containing products. 3. Pregnant or lactating. 4. Tumor in a location where enlargement could cause airway obstruction. 5. Active infection with HIV. 6. Clinically significant viral infection or uncontrolled viral reactivation of EBV, CMV, Adv, BK-virus, or HHV-6. 7. Evidence of acute GVHD \> Grade II or active chronic GVHD \> mild global severity score 8. Currently taking corticosteroids for therapy of GVHD at a dose of \>0.5mg/kg prednisone equivalent 9. Patients who have received Immunosuppressive Treatment (IST) for GVHD within 28 days of infusion 10. Patients who have received donor lymphocyte infusion (DLI) within 28 days of infusion 11. Any of the following cardiac criteria: Atrial fibrillation/flutter; Myocardial infarction within the last 12 months; Prolonged QT syndrome or secondary prolonged QT, per investigator discretion. Cardiac echocardiography with LVSF\<30% or LVEF\<50%; or clinically significant pericardial effusion. Cardiac dysfunction NYHA III or IV (Confirmation of absence of these conditions within 12 months of treatment) 12. CNS abnormalities: Presence of CNS-3 disease defined as detectable cerebrospinal blast cells in a sample of CSF with greater than or equal to 5 WBCs per mm3; History or presence of any CNS disorder such as a uncontrolled seizure disorder, cerebrovascular ischemia/hemorrhage within prior 6 months, dementia, cerebellar disease, or any autoimmune disease with CNS involvement.

Study Info

Interventions

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