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Bispecific Antibody Targets

Last updated on: 8/1/2024

What bispecific antibody therapies are being tested in multiple myeloma clinical trials?

Current research is exploring bispecific antibodies that target various molecules on myeloma cells, including:

  • B-cell maturation antigen (BCMA): This is a protein highly expressed on the surface of myeloma cells, making it an attractive target for bispecific antibodies.
  • G protein-coupled receptor class C group 5 member D (GPRC5D): This is another protein found on myeloma cells being investigated as a target for bispecific antibodies.
  • Fc receptor-like 5 (FcRL5): This molecule helps protect myeloma cells from being attacked by the immune system.  Bispecific antibodies targeting FcRL5 aim to block this protective mechanism, allowing the immune system to eliminate myeloma cells.