Talquetamab Taste Changes in Multiple Myeloma: What Helps and What Doesn’t? -TALISMAN Study | #IMS26

Rakesh Popat, MD, PhD, of University College London Hospitals discusses updated TALISMAN results on taste changes with talquetamab (Talvey) at IMS 2026 in Glasgow. Using taste strips, the study found that sweet and salty tastes are lost most, while others tend to stay. Taste changes peak around three months and then improve. None of the medicines tested to prevent taste loss helped. He also shares how patients can adjust their diet to cope with taste changes, dry mouth and weight loss.

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Timestamps:

0:00 Introduction: Dr. Rakesh Popat, University College London Hospitals

0:11 The TALISMAN Study and Talquetamab Side Effects

0:59 How the Study Measured and Tried to Prevent Taste Loss

1:31 Results: Sweet and Salty Tastes Are Lost Most

1:50 Eating Tips for Taste Changes

2:10 Medical Interventions That Didn't Help

2:27 Summary: Changes Peak at Three Months