BETA - What are the different survival terms?

[Music] What is progression Free survival? So progression free survival means the time interval between the patients getting on the study to the time that they are showing either a biochemical progression or a clinical relapse. So the definition of progression or relapse are defined by the International Myeloma Working Group. Generally for biochemical progression, patients can be asymptomatic, but they've had 25% or more increase in their myeloma markers. And with two consecutive readings or a clinical relapse is someone who is presenting with a new clinical problem. They're either anemic, they start developing new bone pains or renal insufficiency in a things that we attribute to myeloma. That's the time cutoff. And that measure of time. As for progression free survival. Median overall survival is the point in time at which 50% of the patients in the experimental arm have or control arm have died. event free survival is patients not having any type of essentially significant adverse events such as death or progression of their cancer. And it's the time for that. And it's at the time at which half of the patients have had something. Is the event free survival of that particular trial. Progression free survival, is where half of the patients have progressed with their disease. They also have to be alive. If a patient dies, even if it's not due to the disease that is counted as an event for progression free survival. [Music]