Video

How are IMiDs and CELMoDs being explored in combination with CAR T-cell therapy?

Posted by
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• March 24, 2022

Description

Learn about IMiDs and CELOMoDs in CAR-T cell therapy in this HealthTree University lesson by a cancer specialist.

On this video

Healthtree contact Oliver Van Oekelen, MD, PhD

Oliver Van Oekelen, MD, PhD

Icahn School of Medicine at Mount Sinai

Transcript

How are imids and cell mods being explored in combo with CAR T cell therapy? Imids and cell mods have the effect that they activate T cells and we know that T cells contribute to anti-tumor immunology and so the next step that is being studied right now is how these imids or cell mods can impact the efficacy of CAR T because obviously in CAR T what you're doing is treating patients with genetically modified T cells and I know that there are studies ongoing that are specifically looking at treating patients post-CAR T with imids or cell mods because these agents are oral agents so it's generally relatively easy to include them in a treatment regimen and we are studying whether or not this improves the efficacy and sort of the functionality of CAR T cells after you infuse them.