My father is 69 and was diagnosed Jnauary 2024 with 1Q gain. Induction therapy started with VRD for 5 cycles till velcade withdrawn due to PN. SPEP came down to 0.6 from 2.65. Maintenance started with RD till bone pain started and when SPEP measured was found to be 1.2 Doctor brings back velcade and replaced Lenalidomide with Pomalidomide 2mg. Cycle timings dint coincide and as bone pain was persisting, SPEP and PET scan was conducted after 2 cycles of velcade and 1 cycle of Pomalidomide. SPEP is 1.3, and PET has new lesion and impression being progressive disease. Doctor says refractory to both immunomodulatory and bortezomib but I thought differently about Pomalidomide because it was relatively short time to conclude so of Pomalidomide. What do I do, confused really.