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Janine
Multiple Myeloma Discussion • August 4, 2025
'Background' Comment on ClonoSEQ: Anyone Else?
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I was diagnosed in January 2021 with high risk oglisecretory Lambda IgA mm. I was on the quad induction before ASCT in September, 2021. I’m currently on just Dex and FastPro. I have had 8 bone marrow biopsies with LOD of low numbers (no more than 24 and trending at 4-7). Although these seem to be good numbers, my IgK sequence A is what drs are following. This is the comment I have received from all 8 biopsies: “Given LOD per million (see page 3) and tracking behavior, it is possible that the presence of IgK Seq A in this sample may reflect “background “ rather than the initial clone of interest.” I guess this is uncommon. My bone marrow sample last time was over 4 million cells collected. Anyone else with this comment on their ClonoSEQ results? Thanks!
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