Hello everyone. I am a 60 year old woman, diagnosed 11-1-21 with IGg Lambda t(4,14) MM. Induction therapy KRd although dose was too high for me. I had an ASCT in June '22 with a different hospital and have been there ever since. I have been MRD neg since the ASCT, thankfully. I am currently on 1 mg Velcade and 5 mg Revlimid. I am currently moderately neutropenic. My ANC has been below .9 since last July. Originally I was told that Velcade would be stopped if my ANC fell below 1.0, then that was changed to .5. I get Neupogen if it is below .9. My ANC keeps falling. Today it is .6, dangerously close to the .5 'severely neutropenic' threshold. Even with Neupogen, my treatment will continue to suppress my immune system. My doctor, department head at a teaching hospital, continues my treatment despite my almost dangerously low ANC and I am worried that I will get very sick. Has anyone ever decided against a treatment for fear that the impact on your immune system is just too dangerous? Thank you for your thoughts.