Good day all: Age 69, female. MM/MGRS (kidney involvement). Four months of induction chemo. ASCT May 28, 2024. Now on Revlimid 10mg. and Darzalex shot monthly. Diagnosed with MGUS in 2015. Stage 3 kidney disease. I have a question? I was looking at my FISH study. Has any one else had a FISH study done with their bone biopsy. The FISH study looks at chromosomes involved with MM. My FISH was rather discouraging. I have 3 abnormalities, Monosomy 13, I have a duplicate 1Q25. I have a translocation at IGH/FGFR3. That makes me a high risk for what is called a "double hit". Is this something else I need to worry about, or is this a common finding with this disease? Just wondering what the FISH study of others showed. One interesting thing I learned is what causes these abnormalities; most of the time they are random mutations that happen in-utero. That was mind blowing learning that fact. I have racked my brain trying to figure out what I could have done to cause this. This is not my fault. I was born with this. I have carried these whack-a-doodle chromosomes all of my life. I live in the country, and driving by fields it seem there is always a crop being sprayed with something. We live 26 miles from a nuclear power plant. Those are the types of things I wondered about. But nope, born that way. Here is hoping 2025 is a much better year for all of us. My husband had a large brain bleed last August and had to have surgery. He is fine now, but 2024 was a tough year.