My wife is 61 year old. She is in good health and used to exercise at least an hour a day five days a week. She was diagnosed with multiple myeloma in July 2024. She had developed three compression fractures of the vertebrae T8,T11 and L1 Over a few days. She also developed high calcium level. She was started on quad regimen, including. Darzalex, Revlimid, Velcade and Dexamethasone. Her bone marrow biopsy shows she has one high risk feature 1q gain. We met with Oncologist after eight weeks of treatment. Her light changes have normalized and M protein has gone down from. 1.2 to 0.1. During our first appointment at the time of diagnosis our Oncologist told us that she will get four cycles of induction therapy followed by stem cell transplant. However, during recent appointment after eight weeks of treatment and bone marrow cytogenetic report at hand, he told us that stem cell transplant Is an option for her but not necessary. He says whether she gets stem cell transplant or not her survival will be the same. So she could skip the transplant and go straight to maintenance therapy with Revelimid and Darzalex. We know that stem cell transplant was being offered as a standard treatment to younger and fitter patients till recently And my wife would fall in that group, but it is also a harsh treatment with some serious side effects. After the recent discussion with our oncologist We are not sure which way to go. We are looking for feedback from patients who were candidates for stem cell transplant, but decided to go straight for maintenance therapy with Darzalax and Revlimid. We would like to know how they are doing and what is their experience so far. Thank you.