I was diagnosed with secondary plasma cell leukemia earlier this year, 10 years after my multiple myeloma dx. I had a good response to one cycle of Kd therapy, while waiting to see if I'd be approved for access to Talquetamab on Compassionate Need basis (it's not yet approved in The Netherlands where I live). I did my step-up in hospital from October 30 through November 7, since release I'm on the every other week injection schedule. Results of labs from blood drawn one month after completion of step-up (and after 1st injection doneas outpatient) found NO plasma cells in circulating blood, and free light chains below reference range. We are thrilled, my husband, my hematology and me! Will need to wait a week for Mprotein results, expecting good news. For me, single agent Talquetamab has shown a fast and deep response against sPCL as well as my myeloma. Praying now that the response will be durable.