I'm in my 4th cycle of Dara KRD and I suddenly developed very swollen feet at the end of cycle 3. I had a doppler done which ruled out blood clots. Then i had my week off (fourth week of cycle) and the swelling resolved. My oncologist at MSK reduced my dex to 20 mg from 40mg. However after starting Cycle 4, the swelling returned but this time with so much pain in my right ankle up to six inches above that. walking with a limp. So at symptomatic care, they performed an x ray and another doppler which were normal. My doctor called in Lasix 20 mg to take for three days, Has anyone on this therapy had similar experiences and were you and the team able to figure out if it was the dex causing the pain as well or was it carfizomib?