I’ve been taking Darzalex for six years now. The last two treatments I seem to have developed GI issues: excess gas/bloating, gut gurgling, appetite suppression, and I’ve vomited once each time - from the next day to 7 days later. The evening is the worst. It does seem to take about a week before I start to feel normal again. I do take Benadryl and Tylenol before treatment and Benadryl each night for about 4-5 days after. I have not used any steroids with my treatment for over a year. I also take Zyrtec daily for non-allergenic rhinitis. Additionally, each treatment seems to trigger some sinus issues for a short time. That side effect has been ongoing for quite some time. Am I the only one? Does anything help you?