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Light Chain Results Varying: Freelite vs. N Latex?
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Hi All - Just wondering when this group will meet up again via video link? How often do we all catch up as a group? I am just starting now to read through the postings of this group. I am excited to find this group and feel that we can share so much info with one another. I was diagnosed with IgG Lamda Nov 22. Lambda light chain is 466 mg/L over Kappa of 9 mg/L, bone marrow 20%, paraprotein 20g/L (or 2 g/dl), in 24-hour specimen paraprotein only 0.01 g/L, PET scan clear, no lytic lesions or plasmacytomas on MRI and other bloods are stable but hemoglobulin on the low side a bit (118 g/l or 11.8 g/dl). I too am always fatigue and catch everything under the sun.
I am wondering what blood test type are used to measure your light chain? My understanding is there are two main assays - Freelite and N Latex. The reason why I ask is that my Lambda levels vary significantly based on which one is used. Based on Freelite assay my light chain is Lambda 466 mg/L over Kappa of 9 mg/L but on the N Latex my light chain is Lambda 2230 mg/L over Kappa 8.86 mg/L - big difference, right? It is my understanding that the IMWG diagnostic guidelines for MM is based on Freelite assay given there is a low correlation between the two assays in clinical practice.
Live long and smoulder.
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