Kyprolis (Carfilzomib) Pom Dex - with Reduced Ejection Fraction Hi everyone, Is anyone on Kyprolis (Carfilzomib) with reduced ejection fraction (LVEF <50%) at baseline? Are you >70 yrs? What Kyprolis dose were you given/able to tolerate? Did you experience Cardiac side effects or toxicity? If so what? Were you able to continue with Kyprolis if you did? Did you need a dose reduction or did you have to stop therapy? Did the cardiac effects reverse or did you experience more long lasting impacts on your cardiac health? Were there other side effects of concern that you experienced? We're in a slow biochemical relapse and this is looking potentially like our next line of treatment and although our Myeloma Specialists do not think and LVEF or 45% is contraindicative for Kyprolis and this is looking like a possibility for our next line of treatment. I am concerned and would love to hear from other patients HAPPY NEW YEAR EVERYONE!