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jadeHedgehog
Multiple Myeloma Discussion • May 15, 2024
Interpreting My First MRD Results?
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I recently received the results from my first ever MRD test after 3 years of treatment for multiple myeloma. I was diagnosed in April 2021, went through 5-6 cycles of initial treatment with VrD, and had a stem cell transplant in November 2021. After the SCT, I started out on Velcade as my maintenance treatment but switched to Ninlaro after having some side effects on the Velcade. I haven't taken Revlimid for maintenance treatment as yet. I have had three bone marrow biopsies, without the MRD test, prior to this. The MRD test I had was through Adaptive Biotechnologies using clonoSEQ. Since this was my first MRD test, the new bone marrow sample was compared to the sample taken when I was originally diagnosed, so I have a limited track record. The report does not state whether I am positive or negative for measurable residual disease. It just states that there were "residual sequences detected" and gives an estimated MRD value of "80 residual clonal cells per million nucleated cells." Does anyone else have experience with interpreting MRD test results and can you tell me if the report generally states whether they are positive or negative? Also, is 80 clonal cells per million nucleated cells a large or small number?
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