Zometa- wondering if anyone has had an adverse reaction upon receiving their first IV infusion. The day after I received the medication, I had hand pain at the thumb joint better known as the CMC joint. The pain was not relieved with Tylenol. The third day my hands were red, swollen, tight and I had limited movement. The pain was excuritating. I was told by my oncologist to take Tylenol and Claritn. Neither helped. I contacted my primary MD the next day and he prescribed prendisone. It took two more days on the steriod to get rid of the pain and swelling. It is now day 8, and I now have intermittent pain in both joints. I definitely had an adverse reaction.