I read that use of Daratumumab can lead to false positive test results for individuals with IgG kappa myeloma protein leading to inaccuracies in determining the complete response. Daratumumab interferes with routine, electrophoretic based M-protein diagnostics. There is a way to parse the effect of Daratumumab from the M-protein by using Hydrashift assay (Sebia) to resolve t-mAb interference on immunofixation. Has anyone experienced this issue? This only affects people with IgG kappa.