Something to be aware of is that an updated pneumonia vaccine, Prevnar 20, has become available and is recommended for anyone who had Prevnar 13 more than five years ago. Especially important for myeloma patients. Addendum: I checked the CDC website and it's a little more complicated than what the general news I read told me. Here is the info for over 65. Check CDC.gov for more on younger people. There's no research on immunocompromised people, but our oncologist says go get any appropriate immunization. It's highly likely to be of some help. Adults 65 Years or Older CDC recommends pneumococcal vaccination for all adults 65 years or older. The tables below provide detailed information. For adults 65 years or older who have not previously received any pneumococcal vaccine, CDC recommends you: Give 1 dose of PCV15 or PCV20. If PCV15 is used, this should be followed by a dose of PPSV23 at least one year later. The minimum interval is 8 weeks and can be considered in adults with an immunocompromising condition, cochlear implant, or cerebrospinal fluid leak. If PCV20 is used, a dose of PPSV23 is NOT indicated. For adults 65 years or older who have only received PPSV23, CDC recommends you: May give 1 dose of PCV15 or PCV20. The PCV15 or PCV20 dose should be administered at least one year after the most recent PPSV23 vaccination. Regardless of if PCV15 or PCV20 is given, an additional dose of PPSV23 is not recommended since they already received it. For adults 65 years or older who have only received PCV13, CDC recommends you: Give PPSV23 as previously recommended.* See Pneumococcal Vaccine Timing for Adults for specific guidance. The incremental public health benefits of providing PCV15 or PCV20 to adults who have received PCV13 only or both PCV13 and PPSV23 have not been evaluated. * For adults who have received PCV13 but have not completed their recommended pneumococcal vaccine series with PPSV23, one dose of PCV20 may be used if PPSV23 is not available. If PCV20 is used, their pneumococcal vaccinations are complete.