I was diagnosed with smoldering myeloma 2.5 years ago. I suspected it (I’m a physician) because of mildly elevated globulin level and foamy urine. I visited my own medical university (I’m retired) and two major medical centers with myeloma expertise. I researched a number of medical journals and reviewed a couple of ongoing studies regarding smoldering myeloma. I decided to use the data gleaned to develop my own cocktail to try to reduce the likelihood of conversion to myeloma since I was considered low-medium risk. My treatment regime includes: 4 grams of curcumin with Piperine twice daily (piperine improves absorption). This has been found to have beneficial effects. 3 grams of DHA and 3 grams of EPA daily (in two divided doses). Both EPA and DHA has caused apoptosis (death) of myeloma cells (in vitro), but I haven’t found clinical studies that have looked at this. 1,500 mg metformin (long acting) in the evening. Metformin use among those with type 2 diabetes has appeared to slow conversion. Although I am not overweight,nor do I have diabetes, I try to eat well (limit snacks) and exercise daily by both aerobic and strength training. That obese people and those with type 2 diabetes seem to have a more rapid conversion to myeloma may well be due to their higher insulin levels, is my suspicion. Both metformin and exercise along with being at a healthy weight reduces insulin levels. I don’t know if my approach is working as I am just one person. But so far my labs have been stable and regularly checked. And yes, my hematologist and internist know of my treatment strategy.