In response to the question about 1q gain. As always, every myeloma profile is different & every patient responds differently to treatment. I was diagnosed with aggressive myeloma 15 years ago (October 2009). It was considered so at least in part because of my FISH profile: 1q gain (4 copies). Since 2010 I have been through 5 lines of treatment, including 2 stem cell transplants (2010 & 2018) and most recently CAR-T therapy (2022). After every line I responded well, and my response to the CAR-T continues to this day. Note that I am 76, take 2 hours of physical exercise everyday, eat healthy, nutritious foods, stay positive whatever the circumstances, and I am optimistic about my survival prospects. These factors may be very important in my overall longevity despite the genetic profile & many lines of treatment. Good luck on your myeloma journeys.