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DavidO
Multiple Myeloma Discussion • September 20, 2025
Body Aches: Lowering Dex or Stopping Benadryl?
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I have a question for those taking Darzalex Faspro. My doctor said I could stop my Dex completely. So I’ve been working my way down from 20mg the day of treatment to 4. I get my treatment on Fridays, and on Monday or Tuesday I get a weird feeling that sort of feels like anxiety, and it’s a sign I need to lay down and take a nap. Usually feel better thereafter. When I was on the higher doses, I would feel a tightness around my midsection as well. I Don’t remember experiencing that when I was down to about 12mg. However at 8mg and 4mg, I was feeling an increase in body aches I guess I would call it. So I tried 12 mg again today with my treatment. I do take a daily Claritin for allergies, so that’s not changed. And I still take 2 Benedryl the day of my infusion. I just realized that I also weaned myself off of 50mg of Benedryl I had been taking nightly to help both with sleep and allergies. I took my last dose Jun 16. I had infusions on June 13 (4mg Dex), July 18 (4mg Dex), August 15 (8mg Dex), and September 19 (today 12mg Dex). I’m beginning to wonder if taking the 50mg of Benedryl nightly was holding these body aches at bay, and it’s the lack of that (not the lower dose of Dex) that is causing an increase in body aches. Has anyone been instructed by their doctor to take Benedryl in the days after infusion in addition to the day of? Any insight would be appreciated. I would love to stop the Dex completely, and if that means taking Benedryl for a few extra days a month, I’m okay with that!
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