I was wondering if anyone had injection site reactions with Kyprolis IV. I have had 3 cycles as part of DKd (Dara only once a month). From the beginning burning $ stinging at infusion site. As cycles progressed., they traveled 5” up my arm. IV first & second in Cycle 3 were mercifully painful. Onc nurse suggested pulling it and starting another vein. I declined since we had about 7 min. to go! Both nights were terrifying: splitting headache; total body burning up (but no fever); body aches. In morning as I forced myself to get moving, these slowly dissipated. My oncologist said it wasn’t an AE but an “Infusion rxn” So I did a thorough online search & found that kry is toxic the endothelial cells lining veins😳. Remedies included diluting Kry w/ dextrose- saline; slower infusion rate; stopping and restarting. Yesterday I had my 3rd kry+ dexameth. I reported my experiences w/ the two previous infusions to the administering nurse and asked if dilution was possible. Given my prior experiences she would not proceed. She contacted my onc. who agreed to add a bag of dextrose+saline. Bingo! Zero pain during or after infusion. Slight headache; slight “body heat”, no feeling like a truck hit me! Just a note for those using or considering Kyprolis. This was MY experience and I hope remedy. Good luck!