So I'm reaching out to anyone on here who has done quadruplet therapy (either dara VRD or dara KRD) and has translocation 11;14. Just wondering how you have responded to your therapy and whether you have decided to proceed to ASCT or defer that to a later time. I have one more treatment left in cycle 5. As of end of cycle 4 my M spike had decreased from 3.05 to 1.18, my kappa has gone from 103 to 21, and my IGg down from 4500 to 1780. i don't think my m spike will go to 0 by the end of cycle 6 but I'd still rather try to extend therapy at least for two more cycles to see how low I can get those levels. Just searching for those of you who may be or have been in the same situation. FYI-I am being treated at MSK.